Twelve28rx

Twelve28rx is an online-only, prescription-based dermatology platform that compounds and ships custom topical medications for acne, rosacea, melasma, photo-aging and hair loss. Products are formulated in-house by U.S.-licensed pharmacists and priced at a mid-range level—typically USD 60–90 for a 30-day supply—after a USD 20 asynchronous e-consultation. Every order is fulfilled by the company’s own pharmacy in Florida and delivered nationwide within 3-5 days. The brand’s core promise is “your prescription, your strength,” letting providers adjust percentages of tretinoin, azelaic acid, niacinamide, spironolactone or minoxidil in a single pump rather than stocking fixed-dose generics. All formulas are silicone-free, fragrance-free, cruelty-free and dispensed in airless pumps calibrated to 0.25 g per actuation for precise dosing. A photo-progress tracker and unlimited provider messaging for 12 months are bundled into the initial consult fee. Customers are 18-40-year-old skincare enthusiasts who follow derm accounts on TikTok/Reddit, want prescription-grade results without office visits, and value transparency on ingredient percentages. They tend to reject multi-step influencer brands, preferring medical-looking packaging and data-backed before-and-after galleries. Twelve28rx competes with tele-derm networks that mail generic tubes and with mass “custom” serum start-ups that lack true drug potency. It differentiates by owning the compounding pharmacy, offering real-time formula tweaks within 24 hours, and publishing exact active percentages on every label—something neither big-box telehealth nor cosmetic customization players provide.